Laser Direct Energy Deposition (DED) 3D Printing of Superalloys synthesizes a decade of pioneering translational research. The book systematically tackles critical challenges in DED of superalloys towards industrial applications, including process modeling, microstructure control, defect suppression, and mechanical property optimization. It also presents a suite of innovative methodologies, such as physics-informed neural networks, gradient laser power deposition, ultrasonic vibration-assisted deposition, and heterogeneous alloy doping. Backed by validated models, the book serves as an indispensable resource. It is tailored for researchers, engineers, and graduate students aiming to master DED technology and its applications in aerospace, energy, and high-value component manufacturing.