Rodent Models of Neurodegenerative Diseases explores neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Lewy body disease, and Prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume, Rodent Models of Neurodegenerative Diseases, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.