Series One Dr Lucinda Edwards (Niamh Algar) is a smart, battle-hardened doctor, but we meet her on a nightmare shift that ends in the death of an opioid overdose patient, Edith Owusu. Despite the support of her medical supervisor, Dr Leo Harris (James Purefoy), Edith's grieving father Sir Anthony Owusu (Brian Bovell), demands an inquiry into Lucinda's actions on the fateful night. Leading the medical investigation are Dr Norma Callahan (Helen Behan) and Lucinda's former colleague, Dr George Adjei (Jordan Kouam). While George feels this was an unavoidable tragedy, Norma is suspicious of Lucinda's behaviour and decisions in the lead up to Edith's death. As the pressure of the investigation intensifies, Lucinda's relationship with husband Tom (Lorne MacFadyen) starts to fracture, and her confident professional exterior begins to crack. Is Lucinda hiding something? Through the cat and mouse thriller of the medical investigation, Malpractice tells the story of a damaged doctor caught up in a dangerous conspiracy. Series Two Tom Hughes plays Dr James Ford, a Psychiatric Registrar in a North Yorkshire hospital. His personal life is a mess, and his colleagues might find him arrogant, but he appears committed to his vulnerable patients. So when he finds himself torn between a new mother attending a routine postnatal check-up and the sectioning of a floridly psychotic woman during a busy on-call shift, no one could predict the terrible consequences. As George and Norma uncover a hospital seemingly at war with itself, to what lengths will James go to preserve his position? Is he a doctor with a God complex or the victim of wider problems?