This book, Advances in Aerospace Engineering: Artificial Intelligence, Structures, Materials, and Optimization, explores cutting-edge AI and machine learning methods that are revolutionizing aerospace and aviation. With chapters covering key topics such as AI-driven research, structural analysis using Python, optimization of aircraft design, and the future of high-strength materials like borophene, the book provides insights into how recent advancements contribute to efficiency, sustainability, and innovation in the industry. From energy-efficient UAV routing to sustainable aviation fuels, each chapter offers valuable applications and advanced techniques, making this a comprehensive guide for professionals and researchers in aerospace engineering and AI.