In the shadowy closes of Edinburgh's Old Town, sixteen people are murdered to feed surgeon Dr Robert Knox's insatiable need for his anatomy classes. Burke and Hare and their wives, Lucky and Nelly, are all complicit, but only Burke swings for their crimes. Lucky, Nelly and Hare go on the run from the angry mob, reinvention their only means of survival.

Years later, journalist Duncan Fletcher hears rumours of sightings of the two women. Keen to impress his editor, Duncan investigates the aftermath of the murder trial. With cobbler Joseph Campbell in tow, Duncan's quest leads him to the backstreets of London, where the horrors of the past collide with the present.

The time for retribution has come.