Mastery of quality healthcare and patient safety begins the moment clinicians and administrative staff start acquiring practical experience. The acquisition of experience includes more than sensory motor skills and basic science knowledge. It relies on effective reasoning, decision making, and communication shared by all health professionals. This book blends and integrates the fundamentals of reasoning with clinical reasoning and explores decision-making based on the best evidence and communication. It also factors in the assessment of risks, diagnosis, treatment, and prognosis in evidence-based medicine.