The Bone Collector is striking terror amongst the residents of New York City. In desperation, the cops turn to Lincoln Rhyme, an ex-NYPD forensics expert left paralysed after an accident on the job. Rhyme reluctantly postpones his ambitions towards suicide and puts together a forensic investigation team, enlisting as his eyes and ears young police officer Amelia Sachs.

Rhyme digs deep into the only world he has left - his astonishing mind - and slowly begins to narrow the noose around the Bone Collector. But the kidnapper is narrowing his own noose - around Lincoln Rhyme.