Raised in the African bush country by her zoologist parents, Cady thinks she knows all about the "survival of the fittest". But the law of the jungle takes on a whole new meaning when the home-schooled 15-year-old enters public high school for the first time. Trying to find her place among jocks, mathletes and other subcultures, Cady crosses the meanest species of all - the Queen Bee, aka the cool and calculating Regina, leader of the school's most fashionable clique, The Plastics. When Cady falls for Regina's ex-boyfriend, though, the Queen Bee is stung - and she schemes to ruin Cady's social future. Cady's own claws soon come out as she leaps into a hilarious "Girl World" war that has the whole school running for cover.