This edited collection of papers explores from an interdisciplinary perspective the role of images and objects in early modern knowledge-making practices with an emphasis on mapping methodological approaches against printed pictures and things. The volume brings together work across diverse printed images, objects, and materials produced c. 1500-1700, as well as well as works in the ambit of early modern print culture, to reframe a comparative history of the rise of the ‘epistemic imprint’ as a new visual genre at the onset of the scientific revolution. The book includes contributions from the perspective of international scholars and museum professionals drawing on methodologies from a range of fields.