As one of the world's leading scientists examining how our DNA shapes differences in temperament, temptation and behaviour, Harden has seen first-hand how we - in public and in our most private relationships - continue to struggle with the ancient tensions between nature and nurture, freedom and constraint, the desire to punish and the longing to forgive.

In Original Sin, she weaves together insights from her own experience as a daughter, mother, wife and scientist with cutting-edge research in genetics and psychology to grapple with some of the most important questions in modern life: How do we take responsibility for the people we become, knowing how we are shaped by both biology and experience? How should we respond when people hurt each other - or themselves? And has science made guilt obsolete?

Navigating the psychological and biological terrain of addiction, antisocial behaviour and violence, Harden confronts the discomforting ways science unsettles our understanding of wrongdoing and choice. In doing so she asks us not to absolve, but to reckon differently with notions of fairness and blame. A revelatory inquiry into the uneasy space where human behaviour meets inherited biology, Original Sin challenges us to imagine a more humane vision of accountability - for ourselves and for one another.