The book presents fundamental to advanced concepts of AI and IoT in healthcare and disease prediction, demonstrating the emerging mechanisms, including machine learning, deep learning, image sensing, and explainable AI models to handle issues in healthcare industries with real-life scenarios. Included chapters are contributed by experienced professionals and academicians who examine severe diseases, applications, models, tools, frameworks, case studies, applications, and best practices in Healthcare. This book integrates the medical domain with AI technology. It covers trending explainable AI, computer vision (CV), and IoT that facilitate automation for healthcare solutions and medical diagnostics. The primary focus on explainable AI uncovers the black box of deep learning and bridges the distance between medical professionals and technologists. IoT in Healthcare: provides a mechanism of image sensing and is helpful in surgical tools.