In 1693, the settlers on the small Maine island of Sanctuary were betrayed to their enemies and slaughtered. Since then, the island has known three hundred years of peace. Until now. For men are descending on Sanctuary, their purpose to hunt down and kill the wife of their leader and retrieve the money that she stole from him.

All that stands in their way are a young rookie officer, Sharon Macy, and the island's strange, troubled policeman, the giant known as Melancholy Joe Dupree. But Joe Dupree is no ordinary policeman. He is the guardian of the island's secrets, the repository of its memories. He knows that Sanctuary has been steeped in blood once; it will tolerate the shedding of blood no longer. Now a band of killers is set to desecrate Sanctuary and unleash the fury of its ghosts upon themselves and all who stand by them. On Sanctuary, evil is about to meet its match.