Missy already defeated her former best friend, the supervillain Melvira, in an epic showdown, so how hard can making friends at middle school be? But when a “reformed” Melvira suddenly enrols at Missy’s school and wants to run for student body president ... Missy knows in her gut that Melvira and her league of supervillains must be up to evil again. After food fights and catfights, Missy and Melvira land in detention together, where they’re reminded of how great their friendship used to be. And maybe they could they be friends again—but that didn’t go so well the first time ... Then a cursed bunny head begins to turn their town into zombies and the two may have to team up once more to fight the greater evil. Can the former best friends turned archenemies still be true sisters-in-trouble?