Prisoners of War is a drama about three Israeli soldiers who were captured seventeen years ago while on a secret mission with their unit in Lebanon. The story begins with their return home, after years of negotiations for their freedom. Two soldiers return to Israel alive, the third comes home in a coffin.

The series explores the soldiers' reintegration into Israeli society on a national and personal level. However, while the soldiers are acclimating to their lives, a secret investigation is also unfolding about the truth of their capture and the many discrepancies in the soldiers' stories. As the investigators get closer to finding out the truth of what happened in captivity, the two soldiers are even more resolute to do anything they can to hide the biggest secret of all.

Season two picks up where season one ended - Nimrode and Uri are shocked to discover that Amiel Ben Horin is alive and living as a Muslim in Syria. The two contact Haim and implore him to investigate. Has Amiel been turned? Has he joined the terrorist organization that kidnapped and held them for 17 years? All the while, Amiel is torn between his allegiance to family and homeland, and a chance to live a new free life.