Series 1 ended on a cliff-hanger. Is Charlie dead or alive? Is Roo free of the curse that claimed twenty-two? Roos (Alison Bell) world is turned upside down when she meets Marcus (Damon Herriman), somebody stricken with a vaguely similar set of mysterious circumstances to the ones plaguing her although Marcus is a little different from Roo. In fact, he is her opposite. Everybody he has sex with is healed. With EJ (Celia Pacquola) as her somewhat reluctant co-pilot, Roo embarks upon a journey to wipe the slate clean emotionally, physically, spiritually.