In a radical and shocking two-hour film, Waldemar Januszczak finally reveals the true meaning, which has laid hidden for 500 years, behind Michelangelo's greatest masterpiece: the ceiling of the Sistine Chapel in Rome. Januszczak has been studying Michelangelo's masterpiece for 20 years, trying to crack the pictorial code that conceals its startling meaning. Now he has embarked on a journey, taking him from Texas to Jerusalem, in the footsteps of Columbus and all around Italy, to solve the vital clues that reveal, for the first time, the crucial and worrying answers to one of the world's most enduring art mysteries.