In 2004, Eric Clapton assembled a who's who of guitar masters for the first Crossroads Guitar Festival, raising funds for the Crossroads Centre, Antigua, a chemical dependency treatment and education facility Clapton founded after his own legendary struggles with drugs and alcohol. The sold-out show yielded a double-DVD that has been certified eight times platinum (3 x platinum in Australia alone) in the US, becoming one of the world's top-selling music DVDs.

In July 2007, Clapton invited old friends and new for another Crossroads Guitar Festival in Chicago.

Filmed in HD, the 2 DVD set contains four hours of legendary musicians in solo performances and jamming together, along with remarkable footage taken backstage at this six-string summit. Clapton explains "The Crossroads Festival is the realization of a dream for me, to gather a group of amazingly talented musicians to perform onstage The Crossroads performers are all musicians I admire and respect."

With 38 tracks, CROSSROADS showcases a wide range of artists from rock, country, jazz, and blues including performances by : John Mayer, Jeff Beck, Eric Clapton, Sheryl Crow, Robert Cray, Buddy Guy, BB King, Los Lobos, Willie Nelson, Robbie Robertson, Derek Trucks, Steve Winwood, Johnny Winter and many more.