Ever since the late 1960s and early 1970s both as a solo artist and with his band, Santana, Carlos Santana pioneered a fusion of rock and Latin American music, with his melodic, blues-based guitar lines set against Latin and African rhythms featuring percussion instruments not generally heard in rock music. Santana continued to work in these forms over the following decades. He experienced a resurgence of popularity and critical acclaim in the late 1990s.

In 2003 Rolling Stone magazine listed Santana at number 15 on their list of the 100 Greatest Guitarists of All Time. He has won 10 Grammy Awards and three Latin Grammy Awards.

This album collects some of Santana's classic hits, as well as some of his more recent collaborations from the late 90's and 00's.