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Small-town stoner Mike Howell (Jesse Eisenberg) spends most of his time getting high and writing a graphic novel. What Mike doesn't know is that he was trained by the CIA to be a lethal killing machine. When the agency targets him for termination, his former handler activates his latent skills, turning the mild-mannered slacker into a deadly weapon. Now, the utterly surprised Mike must use his newfound abilities to save himself and his girlfriend from getting smoked.