Three girls from Townsville, USA, team-up to fight crime before bedtime.

The city of Townsville is lucky it doesn't have a leash law, because it's time to unleash The Powerpuff Girls again in season five! Him brings back the Rowdypuff Boys and the girls are forced to team up with Princess to defeat the rough and tumble troublemakers. Back at home, our heroines learn some valuable lessons when they take in The Talking Dog, unravel a stuffed animal amputation mystery, and get to the bottom of a bed-wetting incident. And it all comes to a screeching halt when Parents Against Powerpuff put a stop to their crime fighting. Isn't that silly? Thinking you can stop The Powerpuff Girls.